Solutions to accelerate your
We offer the most validated comprehensive liquid biopsy platform on the market to help you chart a path forward to the next phase of your precision oncology drug development. Partner with Guardant Health to accelerate your translational research by better understanding innate and acquired mechanisms of treatment response and resistance, molecular response, and longitudinal monitoring.
Understand tumor evolution and mechanisms of resistance
Our tests reveal more actionable alterations and detect heterogeneously-distributed mutations, which are often missed by hot-spot tests. This provides deeper insights for your translational research into how tumors evolve, and how mechanisms of resistance form.
Acquired resistance post-treatment (osimertinib)
Acquired resistance mechanisms post-osimertinib in locally advanced or metastatic NSCLC whose disease has progressed with previous EGFR TKI therapy and whose tumors harbor a T790M mutation within the EGFR gene Source: Papadimitrakopoulou (Mok) et al. ESMO 2018 Oral Presentation
Gain insights into molecular response to treatment
Use early on-treatment changes in circulating tumor DNA (ctDNA) to predict response and/or outcomes to immunotherapy or targeted therapy across solid tumors including confirming target inhibition or drug mechanism of action.
ctDNA predicts responders on average 8 weeks earlier than RECIST criteria
ctDNA molecular response identifies RECIST responders earlier. Source: Zhang (Hellman), et al 2020 Prognostic and predictive impact of ctDNA in patients with advanced cancers treated with immune checkpoint blockade; Cancer Discovery; DOI: 10.1158/2159-8290.CD-20-0047
Progression-free survival is longer in molecular responders across therapies and cancer types
Molecular response predicts clinical outcomes across multiple therapies and cancer types Source: 1 Raja (Ranade) et al. 2018 Clin Cancer Res; 2 Thompson (Aggarwal) et al. 2021 JCO PO; 3 Kim (Kang) et al. 2018 Nat Med; 4 Shaw (Solomon) et al. 2019 JCO 37(15) abstr 9019; 5 Mack (Gandara) et al. 2020 JCO 38(15) abstr 9532; 6 Maron (Janjigian) et al. 2020 JCO 38(15) abstr 4559; 7 Modi (Park) et al. 2020 JCO 38(15) abstr 1036
Monitor longitudinal treatment response
Using our Guardant360 liquid biopsy tests, you can easily track patient tumor burden over time, with serial blood draws for earlier insights into who is responding, who is not responding, and why.
Disease progression at various time points
Monitoring disease trajectory: case example targeting an ALK fusion and subsequent ALK resistance mutations. Source: DOI: 10.1158/1078-0432.CCR-17-2588